Hmmm, if it happens at a different venue then I'd start suspecting the gear.
Until then, I'd suspect something at the venue itself.
Things that might only interfere occasionally:
* mobile phone (registers with the network about once every 20 mins)
* smoke machine (Heating element on intermitently to maintain operating temp
* Air conditioning fans/motors at venue
* Are these the newer mackie 450's with a temp controlled fan?
* Dodgy Mobile Licensed bar with poorly maintained/unsuppressed pumps/coolers
* Some dastedly evil new noise limiter - controlling the DJ's desire for good audio, rather than the sockets...